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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: REL All Species: 13.33
Human Site: S557 Identified Species: 29.33
UniProt: Q04864 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04864 NP_002899.1 619 68520 S557 S N T T V F V S Q S D A F E G
Chimpanzee Pan troglodytes XP_001159537 619 68348 S557 S N T T V F V S Q S D A F E G
Rhesus Macaque Macaca mulatta XP_001115312 619 68464 S557 S N T T V F V S Q S D A F E G
Dog Lupus familis XP_531836 593 65808 P530 S S T T A F V P Q P E A F E G
Cat Felis silvestris
Mouse Mus musculus P15307 587 64942 F526 G T S S S S V F V S Q S D A F
Rat Rattus norvegicus NP_954888 550 60249 S487 Q G V A M S H S T A E P M L M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512346 573 64146 S509 S C A A P F V S Q S E A F D S
Chicken Gallus gallus P16236 598 66829 A536 Q P N L A D T A V Y N S F L D
Frog Xenopus laevis Q04865 527 59040 Q466 L Q E P G T S Q G T F M A Y P
Zebra Danio Brachydanio rerio NP_001001841 596 67208 L522 N H Q P G I Q L K Q E P Q G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15330 999 111533 Q904 R R T A S A L Q L A D I P I S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.7 81.7 N.A. 71.2 38.6 N.A. 59.6 49.4 41.8 44.5 N.A. 25.5 N.A. N.A. N.A.
Protein Similarity: 100 99.5 98.3 86.4 N.A. 79.6 54.9 N.A. 69.3 64.3 56.2 58.3 N.A. 38.8 N.A. N.A. N.A.
P-Site Identity: 100 100 100 66.6 N.A. 13.3 6.6 N.A. 53.3 6.6 0 0 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 80 N.A. 33.3 26.6 N.A. 66.6 26.6 6.6 26.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 28 19 10 0 10 0 19 0 46 10 10 0 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 37 0 10 10 10 % D
% Glu: 0 0 10 0 0 0 0 0 0 0 37 0 0 37 0 % E
% Phe: 0 0 0 0 0 46 0 10 0 0 10 0 55 0 10 % F
% Gly: 10 10 0 0 19 0 0 0 10 0 0 0 0 10 37 % G
% His: 0 10 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 10 0 10 0 % I
% Lys: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % K
% Leu: 10 0 0 10 0 0 10 10 10 0 0 0 0 19 10 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 10 10 0 10 % M
% Asn: 10 28 10 0 0 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 10 0 19 10 0 0 10 0 10 0 19 10 0 10 % P
% Gln: 19 10 10 0 0 0 10 19 46 10 10 0 10 0 0 % Q
% Arg: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 46 10 10 10 19 19 10 46 0 46 0 19 0 0 19 % S
% Thr: 0 10 46 37 0 10 10 0 10 10 0 0 0 0 0 % T
% Val: 0 0 10 0 28 0 55 0 19 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _